PURPOSE To determine the influence of drug lipophilicity, ocular pigmentation, and species differences on transscleral solute transport. METHODS The transport of eight β-blockers across excised sclera/sclera-choroid-RPE (SCRPE) of albino rabbit, pigmented rabbit, human, porcine, and bovine eyes was determined over 6 hours. The ex vivo transscleral β-blocker transport to the vitreous at the en...

PURPOSE To study the value and safety of staining the anterior lens capsule in albino rabbits. SETTING Ophthalmology Department, Cairo University, and Ophthalmic Pathology Department, Research Institute of Ophthalmology, Cairo, Egypt. METHODS The experiment was divided into 3 stages. First, the capacity of different concentrations of crystal violet solution to stain the anterior lens capsul...

Using a rabbit model we investigated the role of pigmentation of the ciliary body in obtaining ciliodestruction by neodymium-YAG transscleral cyclophotocoagulation. There was marked destruction of the ciliary body in pigmented rabbit eyes, but no histologic effect was observed in albino rabbit eyes. These findings suggest that pigmentation of the ciliary body is important for obtaining the desi...

Antipyretic effect of ethanolic extract of the leaf of plumeria rubra was investigated. Intraperitoneal administration of boiled milk at a dose 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i. p. route) administration of ethanolic extract of the leaf of plumeria rubra at a dose 200mg/kg body weight were shown significantly reduce the elevated body temperature of rabb...

Occupational tar cancer, or the development of malignant epithelial tumors in those whose work entails prolonged exposure to tar or to certain closely related substances, has for many years constituted a recognized clinical entity. The close causal relationship between chemical agent and tumor development apparent in these cases has stimulated numerous attempts during the last forty years to pr...

Recent histochemical studies with the use of a fluorescence method to detect catecholaminecontaining neurons have uncovered a system of dopamine-containing amacrine cells as toell as a plexus of norepinephrine-containing nerve terminals in the choroid. This study examined the effect of dark and light adaptation on the catecholamine content of the posterior segment of the eye of the albino guine...

PURPOSE To determine whether intravitreal injection of trypan blue is toxic to the retina of the albino rabbit. METHODS Sixteen albino rabbits were studied for the effects of intravitreal trypan blue (eight with 0.06% solution and eight with 0.15% solution). Saline was injected into the fellow control eye of all rabbits. The electroretinogram and visual evoked potentials were recorded from ea...

PURPOSE Intravitreal indocyanine green (ICG) is commonly used in vitreoretinal surgery. The purpose of this study was to evaluate possible toxicity of ICG in the retina of albino rabbits. METHODS Twenty-two albino rabbits were injected intravitreally with 0.1 mL ICG solution in one eye, and three rabbits were studied for the effects of 0.1 mL distilled water. All rabbits were injected intravi...

PURPOSE This study was designed to investigate the possibility that gentamicin-induced retinal toxicity is dependent on ocular pigmentation by comparing the effects of the drug on the functional and morphologic integrity of the retina in albino and pigmented rabbits. METHODS In each rabbit, a solution of gentamicin sulfate was injected into the vitreous of one eye, and saline was injected int...

PURPOSE To study the risk of adverse events in transpupillary thermotherapy (TTT) for age-related macular degeneration by measuring how laser-induced retinal temperature increase is affected experimentally by subretinal blood, choroidal blood flow, and chorioretinal pigmentation. METHODS An ultrafine thermocouple technique was developed to measure retinal temperature increase during TTT in al...